The feeding tube no one can see

The Alsteni System anchors inside the mouth using orthodontic-grade components and retracts completely between uses. No tube on the face. No surgical opening. A fundamentally new approach to enteral feeding.

Published in Nutrition & Diabetes · FDA Pre-Submission Complete · USC Techstars '25
TPA Molar anchor Jejunum ↓
Supported by USC Techstars '25 · NSF I‑Corps · Coulter Foundation Advisors from Mayo Clinic · Columbia · USC Keck · U. Adelaide Supported by USC Techstars '25 · NSF I‑Corps · Coulter Foundation Advisors from Mayo Clinic · Columbia · USC Keck · U. Adelaide
550,000+
Americans depend on tube feeding each year. The tubes work. The experience doesn't.

Patients who depend on enteral nutrition skip family gatherings, avoid photographs, and eat alone — not because the devices fail medically, but because the experience is intolerable. The visibility and discomfort of traditional tubes lead many to withdraw from daily life, and some to refuse treatment altogether. Today's options force an impossible choice: a nasogastric tube taped across the face, or a gastrostomy tube — a surgical opening in the abdomen. In more than four decades, no fundamentally new approach has reached patients.

Today's standard
Nasogastric Tube
  • Taped across the face — visible to everyone

    A prospective study found 53% of NG tube patients reported significant body image disturbance, with many describing feelings of shame, embarrassment, and social withdrawal directly linked to the tube's facial visibility.

    Ojo et al., Journal of Human Nutrition and Dietetics, 2019

  • Dislodges regularly, requiring reinsertion

    NG tube displacement rates range from 21–58% across published studies. Each reinsertion carries risk of misplacement into the lungs, with reported rates of pulmonary insertion between 1.3–2.4% — a potentially fatal complication.

    Sparks et al., Nutrition in Clinical Practice, 2011; Metheny et al., American Journal of Critical Care, 2019

  • Patients report avoiding social situations and public spaces

    Qualitative research shows tube-fed patients consistently describe social isolation as a primary burden — avoiding restaurants, declining invitations, and eating in private. Visibility is cited as the leading reason patients decline NG tubes.

    Brotherton et al., Journal of Human Nutrition and Dietetics, 2006; ASPEN Clinical Guidelines, 2024

or
Today's standard
Gastrostomy (PEG) Tube
  • Requires a surgical opening in the abdomen

    PEG placement carries a procedure-related mortality rate of 0.5–2% and a 30-day mortality as high as 24% in certain elderly populations. Despite being intended as "temporary," many patients retain PEG tubes for years due to the invasiveness of removal.

    Defined for removal: Rahnemai-Azar et al., International Journal of General Medicine, 2014; Janes et al., BMJ, 2005

  • Daily wound care and ongoing infection risk at the stoma site

    Peristomal wound infections occur in 4–30% of PEG patients, making it the most common complication. Other risks include buried bumper syndrome (0.3–2.4%), peritonitis, and tube migration — each requiring additional clinical intervention.

    Blumenstein et al., World Journal of Gastroenterology, 2014; Hucl & Spicak, Best Practice & Research Clinical Gastroenterology, 2016

  • Permanent scarring, even after removal

    After PEG removal, persistent gastrocutaneous fistula occurs in up to 44% of patients, often requiring surgical closure. All patients are left with a visible scar. For patients whose underlying condition resolves, the physical reminder of the tube remains indefinitely.

    Löser et al., Endoscopy, 2005 (ESPEN Guideline); Gordon & Lovat, Frontline Gastroenterology, 2019

How It Works

Three steps. Then it disappears.

A routine dental visit. A bedside placement. Then nothing visible — anywhere. The Alsteni System is designed so that between uses, there is no indication a patient is tube-fed.

Anchor
Place
Retract
01
Anchor Placement
A general dentist places the Alsteni Anchor™ — orthodontic-grade molar bands connected by a transpalatal arch. No surgery. No sedation. A routine dental procedure.
Routine dental visit No surgery No sedation
02
Tube Placement
A physician threads the Alsteni Tube™ through the anchor and into position. The tube locks to the anchor and is replaced approximately every 30 days.
Physician-placed Locks to anchor Replaced monthly
03
Between Uses
When feeding is complete, the tube retracts behind the teeth. Nothing is visible on the face, neck, or body. No one knows unless the patient chooses to tell them.
Fully retractable. Nothing visible. Complete discretion.
Click to advance

Grounded in published, peer-reviewed research.

The Alsteni System builds on a foundation of IRB-approved clinical research published in peer-reviewed journals. Our work is transparent, our data is public, and our next study is in development.

Beale et al., 2020 — Nutrition & Diabetes

Journal: Nutrition & Diabetes (Nature Portfolio) · PMID: 32555148

Design: IRB-approved feasibility study evaluating an intraorally-anchored feeding tube in adults.

Key finding: The study completed 334 tube-days with zero serious adverse events, establishing an initial safety signal for the intraoral anchoring approach.

Beale et al., Nutrition & Diabetes, 2020 (PMID: 32555148)
Safety
334 tube-days · Zero serious adverse eventsThe study observed no dislodgements requiring emergency intervention across all patients and tube-days.
IN DEVELOPMENT
Next: OASIS-90
~25–30 patients · 60–90 daysProspective feasibility study. Academic lead: Creighton University. Focus: tolerability, nutrition adequacy, and safety with the production-design device.

One platform. Designed to grow.

The Alsteni System is a modular enteral feeding platform. The same anchor, tube, and adapter architecture is designed to support multiple clinical applications — beginning with enteral nutrition.

Alsteni Nourish

For patients who depend on tube feeding

The initial application of the Alsteni System: delivering enteral nutrition through an intraorally-anchored tube that is invisible between uses. Currently pursuing FDA 510(k) clearance.

510(k)
Regulatory pathway
Enteral nutrition
Initial indication
Future Indications

A platform built for expansion

The modular architecture of the Alsteni System is designed to support future clinical applications beyond enteral nutrition. Additional indications would require separate regulatory submissions and clinical evidence. Our focus today is on clearing the foundational platform.

Modular
Platform architecture
Separate
Regulatory pathway per indication

Built by operators. Guided by experts.

42 issued patents. $1B+ in commercialized medical device revenue. Published researchers. Former FDA reviewers. A team built to take this from prototype to patients.

Elizabeth Beale, MD
CEO & Lead Inventor
Board-certified endocrinologist. 30+ years clinical experience at LAC+USC Medical Center. Associate Professor, USC Keck School of Medicine. Lead inventor, U.S. Patent 10,744,070 B2. Published researcher in enteral nutrient delivery and gut hormone physiology.
Nicholas Demetriades
President & Co-Founder
Commercial strategy, fundraising, and investor relations. USC Techstars 2025. Former U.S. Marine (infantry/artillery). Leads all capital raising, partnership development, and go-to-market planning.
Arieh Halpern, MS
COO
25+ years in medical device commercialization. $1B+ cumulative revenue across 10+ Class II/III devices. Former Medtronic Diabetes, Boston Scientific. Leads manufacturing, supply chain, and operational scale-up.
Todd Oda, BS
CTO
42 issued patents. Led development of the Ormco Damon System ($150M+ annual revenue), 3M Victory Series, and InBrace Gen 2. Expertise in orthodontic devices, catheter connectors, and superelastic materials.
Advisory Network
Dr. Dror Dicker
Free2Go PI · Rabin Medical Center, Israel
Dr. John Anwar
OASIS-90 Lead · Creighton University
Kwame Ulmer
Former FDA CDRH Reviewer · Regulatory Strategy
Dr. Demetrios Demetriades
USC Division of Trauma Surgery
Dr. David Seres
Columbia University · ASPEN Board
John Tong, MBA
Co-founder InBrace · Raised $173–219M