Built by operators.
Guided by experts.

63 issued patents. $1.5B+ in commercialized medical device revenue. Published researchers. A former FDA reviewer. A team assembled to take an idea from published feasibility data to FDA clearance and commercial launch.

63 patents across the leadership team — primarily through CTO Todd Oda’s 51 issued patents across orthodontics, catheter systems, and medical connectors at Ormco, 3M, InBrace, and Becton Dickinson.
63
Collective team patents
Primarily through COO Arieh Halpern’s work at Medtronic Diabetes, Cardiac Science, and GE Healthcare — 100+ products commercialized across Class II/III devices including Guardian Connect CGM.
$1.5B+
Commercialized device revenue
From the Alsteni feasibility trial (Beale et al., Nutrition & Diabetes, 2020). Zero serious adverse events across all patients — the clinical evidence that anchors the 510(k) pathway.
334
Tube-days in feasibility trial
Advisors and operators spanning Mayo Clinic, Columbia, University of Adelaide, USC, and former FDA CDRH — covering regulatory, clinical, engineering, and commercial domains.
6
Scientific advisory board members
Tap any number for context ↑

The core team

A physician who invented the device, an operator who builds the business around it, an executive who has commercialized $1.5B+ in devices, and an engineer with 51 issued patents.

Elizabeth Beale
Elizabeth Beale, MD
CEO, Founder & Inventor
American Board-certified in Internal Medicine, Endocrinology/Diabetes/Metabolism, Obesity Medicine, and Lifestyle Medicine. MRCP (UK). Master’s in Clinical Investigation. Former Associate Professor of Clinical Medicine, USC Keck School of Medicine. Over 30 years of clinical experience including work at the Los Angeles County Department of Health Services, where she directed the Roybal Diabetes Management Clinic and founded the Roybal Lifestyle Management Program.
Lead inventor on three U.S. patents. Published pioneering work on bolus enteral feeding for metabolic management in Nutrition & Diabetes (2020) and Nutrition (2022).
Internal Medicine Endocrinology Obesity Medicine Lifestyle Medicine MRCP (UK) Three U.S. Patents
Full bio
Elizabeth Beale, MD
CEO, Founder & Inventor — Alsteni Medical
Training & Credentials

Board-certified endocrinologist (American Board of Internal Medicine). MRCP (UK). MD from the University of Adelaide, Australia. 30+ years of clinical practice including the Los Angeles County Department of Health Services. Former Associate Professor, USC Keck School of Medicine.

Patents & Invention

Lead inventor on three U.S. patent filings covering the intraoral gastrointestinal access device, dental anchor system, and metabolic therapy protocol. Led the FDA Pre-Submission process (Q252869, December 2025) confirming the 510(k) regulatory pathway.

Clinical Research

Principal investigator on the proof-of-concept study published in Nutrition & Diabetes (Nature Publishing Group, 2020) — 16 patients enrolled, zero serious adverse events across 334 device-days. Co-author, Nutrition (2022). 45+ peer-reviewed publications across endocrinology, metabolic medicine, and gut hormone physiology. Designed the Metabolic Therapy Program protocol based on the DiRECT trial framework adapted for jejunal nutrient delivery.

LinkedIn
Nicholas Demetriades
Nicholas Demetriades
President & Co-Founder
Commercial strategy, business development, and operations. USC Techstars 2025 inaugural cohort. Named inventor on U.S. Patent 12,599,544 (issued April 14, 2026). Former U.S. Marine (0311, Reserves). AI-native operator running the company’s full execution stack — partnerships, go-to-market, CRM, outreach, and fundraising infrastructure.
USMC Reserves — 0311 USC Techstars '25 US Patent 12,599,544
Full bio
Nicholas Demetriades
President & Co-Founder — Alsteni Medical
Background

Washington State University alumnus. USC Techstars 2025 inaugural cohort. Former U.S. Marine — 0311 Infantry, Reserves. Prior to Alsteni, built and ran the digital marketing engine that generated $30M+ in international property sales for Leptos Group — Cyprus’s largest private property developer — on track for Marketing Director before leaving to commercialize the Alsteni System.

Patent & IP

Named inventor on U.S. Patent 12,599,544, "Intraoral Gastrointestinal Access Device and Related Methods," issued April 14, 2026. Co-inventors: Elizabeth Beale, MD (CEO, inventor of record) and Todd Oda (CTO). Part of a portfolio that includes US 10,744,070 (issued, through 2039), a PCT international filing (WO2025235457), and multiple pending continuations.

Operations & Raise

Operates as the sole operational founder, directing AI as a full-stack execution layer across fundraising, investor relations, regulatory strategy, competitive intelligence, and go-to-market — replacing the output of 5–10 early hires. Manages a 2,000+ contact CRM, cold outreach infrastructure, financial models, clinical site coordination, and the company’s full commercial operating system. Currently leading Alsteni’s $4M seed round.

LinkedIn
Arieh Halpern
Arieh Halpern, MS
Chief Operating Officer
25+ years in medical device commercialization. $1.5B cumulative revenue. 100+ products commercialized. 8 patents. Former Medtronic Diabetes. Leads manufacturing, supply chain, and operational scale-up.
As COO, Arieh manages manufacturing partnerships, regulatory strategy, supply chain, and commercial planning. Currently also serves as Cedars-Sinai Techstars mentor.
Medtronic Diabetes $1.5B Device Revenue 100+ Products Commercialized
Full bio
Arieh Halpern, MS
Chief Operating Officer — Alsteni Medical
Career

25+ years in medical device commercialization. $1.5B cumulative revenue. 100+ products commercialized spanning Class II and III devices. 8 issued patents. Former senior roles at Medtronic Diabetes, GE Healthcare, Cardiac Science, and Bear Medical Systems. Founded AdMIT Therapeutics. Former Spacelabs Medical and Sensatex. MS in Biomedical Engineering.

Role at Alsteni

Leads manufacturing partnerships with Medical Murray (tube fabrication), APP Medical (anchor MIM components), and Universal Orthodontics (TPA fabrication). Oversees clinical operations planning for the OASIS-90 trial. Deep expertise in FDA 510(k) and PMA submissions, design controls, and production scale-up from prototype through commercial launch.

LinkedIn
Todd Oda
Todd Oda, BS
Chief Technology Officer
35 years of medical device development experience with 51 issued patents across orthodontics, catheter systems, and medical connectors. Career highlights include leading development of the Ormco Damon System ($150M+ annual revenue), creating the 3M Victory Series Active Bracket and Victory Series Buccal Tubes, and serving as VP of Insights and Development at InBrace where he developed the Gen 2 orthodontic system in a record 5 months.
Todd’s expertise directly applies to Alsteni’s technology: orthodontic design and small-form-factor medical devices (from his work as a product innovation engineer at Becton Dickinson). He has worked extensively with Knobbe Martens (Alsteni’s patent counsel) on intellectual property strategy.
51 Patents Issued Ormco Damon System 3M & InBrace Medical Device Design
Full bio
Todd Oda, BS
Chief Technology Officer — Alsteni Medical
Patents & Career

51 issued U.S. patents in medical device design and orthodontic systems. Led development of the Ormco Damon System ($150M+ annual revenue), the 3M Victory Series Active Bracket and Buccal Tubes, and the InBrace Gen 2 System. Named inventor on multiple Alsteni Medical patent filings including U.S. Patent Application 19/199,999.

Alsteni Device Design

Designed the current-generation Alsteni anchor system addressing all mechanical failure modes from the proof-of-concept study — including the flexible connector with safety mechanisms, revised anchor profile for low-profile molars, and elimination of the sharp edge that caused prototype-related adverse events. Leads product development from Gen 1 production design through Gen 3 non-dental anchor concepts.

Expertise

Orthodontic design, small-form-factor medical devices, design for manufacturability, and metal injection molding (MIM). Former product innovation engineer at Becton Dickinson. Extensive IP strategy work with Knobbe Martens (Alsteni’s patent counsel).

World-class domain expertise

Six advisors from institutions that define the standard of care — spanning gut physiology, enteral nutrition, trauma surgery, clinical nutrition, orthodontic anchoring, and clinical trial oversight.

Prof. Michael Horowitz
University of Adelaide
Prof. Michael Horowitz, AO
Gut Physiology & Nutrition Advisor
H-index 132. Golgi Prize recipient. Among the world’s leading researchers in gut hormone physiology and gastric motility. Co-author with Dr. Beale on the hypothesis paper establishing the scientific rationale for bolus enteral nutrient delivery (Nutrition, 2022).
Dr. Hongsheng Tong
USC / InBrace
Dr. Hongsheng Tong
Orthodontic Anchoring & Intraoral Device Advisor
Raised $173–$219M in venture funding for InBrace. 10,000+ patients treated with intraoral devices. Intraoral device expert whose work directly informs the Alsteni Anchor design. Co-founder, InBrace.
Manpreet Mundi, MD
Mayo Clinic
Manpreet Mundi, MD
Home Enteral Nutrition Advisor
Director, Home Enteral Nutrition Program, Mayo Clinic. ASPEN Dudrick Research Scholar Award recipient. National authority on enteral nutrition practice, outcomes research, and malnutrition management.
Columbia University
David Seres, MD
Clinical Nutrition Advisor
ASPEN Board member. UpToDate editor for nutrition topics. Abbott nutrition advisor. Leading voice in evidence-based clinical nutrition support and nutrition policy.
USC Keck School of Medicine
Demetrios Demetriades, MD, PhD
Trauma Surgery Advisor
Director, Division of Trauma Surgery, LAC+USC Medical Center. Extensive research in critical care nutrition and trauma patient outcomes. Over 800 peer-reviewed publications.
Academic Medical Center
John Anwar, MD
Clinical Study Academic Lead
Academic lead for the FDA-required clinical study. Faculty champion providing IRB infrastructure and clinical trial oversight for the next phase of Alsteni’s clinical evidence generation.

Strategic guidance

Hando Kim
International Expansion
Korea TIPS program specialist. Exploring international partnership opportunities for post-clearance expansion.
Min-Yi Shih
Business Strategy
Strategic positioning and growth advisory. Provides guidance on business model refinement, partnership structuring, and commercial strategy.

The professional infrastructure

The specialized firms and consultants executing the regulatory, IP, reimbursement, and clinical workstreams that move the device toward clearance.

Regulatory Strategy
MedTech Impact Partners
Kwame Ulmer & Ery Anguiano
Kwame Ulmer: former FDA CDRH reviewer — 12 years, 1,000+ device reviews. Led FDA Pre-Submission strategy (Q252869) and ongoing regulatory pathway guidance.
Intellectual Property
Knobbe Martens
Andrew Douglas & Dylan Kramer
Patent prosecution for issued patent and continuation applications. One of the top IP firms in medical devices.
Reimbursement Strategy
Best Laid Plans
Neelima Firth
Phase I engagement completed: CPT code analysis, E&M visit strategy, obesity and enteral feeding reimbursement landscape.
Clinical Protocol
Boulder Clinical Science
Kimberly Martin, PhD
FDA-required clinical protocol development and study design.

The professional infrastructure behind the science.

Want to learn more?

Whether you’re a clinician, researcher, or potential collaborator — we’d welcome the conversation.